Dataset information
Study summary
| Title | Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination. |
|---|---|
| Abstract | Mammalian sex determination hinges on sexually dimorphic transcriptional programs in developing fetal gonads. A comprehensive view of these programs is crucial for understanding the normal development of fetal testes and ovaries and the etiology of human disorders of sex development (DSDs), many of which remain unexplained. Using strand-specific RNA-sequencing, we characterized the mouse fetal gonadal transcriptome from 10.5 to 13.5 days post coitum, a key time window in sex determination and gonad development. Our dataset benefits from a greater sensitivity, accuracy and dynamic range compared to microarray studies, allows global dynamics and sex-specificity of gene expression to be assessed, and provides a window to non-transcriptional events such as alternative splicing. Spliceomic analysis uncovered female-specific regulation of Lef1 splicing, which may contribute to the enhanced WNT signaling activity in XX gonads. We provide a user-friendly visualization tool for the complete transcriptomic and spliceomic dataset as a resource for the field. |
| Publication date | 12. 2018 |
Dataset summary
| Name | data_genelevel |
|---|---|
| Number of sample/cell | 16 |
| Number of classification | 1 |
| Number of Interogated genes | 24500 |
| Technology | RNA-Seq |
| Species | Mus musculus |
Classification parameters
Dataset operations
Dataset summary
| Name | data_genelevel |
|---|---|
| Number of samples/cells | 16 |
| Number of classification | 1 |
| Number of interrogated genes | 24500 |
| Technology | RNA-Seq |
| Species | Mus musculus |
Download full dataset
DownloadGene expression table
data_genelevel - Zhao et al. 2018, Mol. Cell. Endocrinol.
Select your visualisation
Select additional tracks to show
Genes selection
Load your gene lists
To save your gene list, you need to be logged in.
Selected genes
Optional: Select one gene to be displayed
Required : Select one gene to be displayed
Optional: Select one or more genes to be displayed
You can add genes to this list by using the input in Genes selection, or by loading a saved gene list.