Pubmed ID : 29848638
Article Name : The transcription factor SOX30 is a key regulator of mouse spermiogenesis.
Abstract : The postmeiotic development of male germ cells, also known as spermiogenesis, features the coordinated expression of a large number of spermatid-specific genes. However, only a limited number of key transcription factors have been identified and the underlying regulatory mechanisms remain largely unknown. Here, we report that SOX30, the most-divergent member of the Sry-related high-motility group box (SOX) family of transcription factors, is essential for mouse spermiogenesis. The SOX30 protein was predominantly expressed in spermatids, while its transcription was regulated by retinoic acid and by MYBL1 before and during meiosis.
Publication data : 05. 2018
Authors : D Zhang, D Xie, X Lin, L Ma, J Chen, D Zhang, Y Wang, S Duo, Y Feng, C Zheng, B Jiang, Y Ning, C Han
Ome : Transcriptome
Technologies : RNA-Seq
Species : Mus musculus
Experimental design : Normal
Topics : Spermatogenesis, Spermiogenesis, Spermatids
Tissues : Round spermatids
Sex : Male
Developmental stage : Adult
Age : 23dpp
Keywords : Sox30, Spermatids, Spermiogenesis, Transcription factor
Sample count : 4
Jbrowse datasets(s)
Species | Jbrowse |
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Mus musculus | Genome browser |