Pubmed ID : 30893600

Article Name : Dissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell Transcriptomics.

Abstract : Sex determination is a unique process that allows the study of multipotent progenitors and their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary. Using time series single-cell RNA sequencing (scRNA-seq) on ovarian Nr5a1-GFP

Publication data : 03. 2019

Authors : I Stévant, F Kühne, A Greenfield, MC Chaboissier, ET Dermitzakis, S Nef

Ome : Transcriptome

Technologies : scRNA-Seq

Species : Mus musculus

Experimental design : Normal

Topics : Gonad development, Sex determination

Tissues : Gonad somatic cells

Sex : Female, Male

Developmental stage : Fetal, Prepubertal

Age : 10.5dpc, 11.5dpc, 12.5dpc, 13.5dpc, 16.5dpc, 6dpp

Cell sorted : NR5A1-eGFP+

Keywords : single-cell RNA-seq, sex determination, ovary, testis, granulosa cell, Sertoli cells, supporting cells, progenitors, differentiation, lineage specification, cell fate decision, gonad development, gene expression, transcriptomics

Sample count : 1098


Name Species Technology Actions
data genelevel XX Mus musculus scRNA-Seq View Download
data genelevel XX and XY Mus musculus scRNA-Seq View Download

Jbrowse datasets(s)

No jbrowse datasets are associated with this study